|
In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell and a lymphocyte such as an effector T cell or Natural Killer cell. It is the subject of much ongoing research. ==Structure and Function== The immune synapse is also known as the supramolecular activation cluster or SMAC. This structure is composed of concentric rings each containing segregated clusters of proteins: * c-SMAC (central-SMAC) composed of the θ isoform of protein kinase C, CD2, CD4, CD8, CD28, Lck, and Fyn. * p-SMAC (peripheral-SMAC) within which the lymphocyte function-associated antigen-1 (LFA-1) and the cytoskeletal protein talin are clustered.〔 * d-SMAC (distal-SMAC) enriched in CD43 and CD45 molecules. This complex as a whole is postulated to have several functions including but not limited to: *Regulation of lymphocyte activation *Transfer of peptide-MHC complexes from APCs to lymphocytes〔 *Direct secretion of cytokines or lytic granules〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Immunological synapse」の詳細全文を読む スポンサード リンク
|